City break advise?

[Tremulous Tetra]

Would like to try and city break, three nights, below is what I have a choice from.  I really liked Barcelona and Dublin but don't really want to go back their again this time.  Both were ideal for access.  I would really like to go to Rome [anywhere in Italy], Paris, Prague, Valencia, Berlin, Budapest.  Access wise, is there any of those you would warn me off, or any that you would particularly recommend?  I renew the places I missed are particularly worth having look at?  I really like good food, vibrant culture, history and architecture [Barcelona was spot on].  So any advise please.
Sweden
Stockholm


Cheq-Republic
Prague


Spain
Barcelona,Valencia

Granada, Seville ,Girona


Belgium
Brussels


Holland
Amsterdam


Italy
Acona,Genoa,Venice,Pescara

Rome,Pisa,Milan,Verona


France
Nice,Biarritz

Paris, Rodez


Germany
Berlin, Hamburg, Frankfurt


Hungary
Budapest


Poland
Krakow, Wroclaw


Ireland
Dublin


Portugal
Porto

Algarve